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R (+) -Methylindazone

CAT: 0804-HY-12693-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12693-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R (+) -Methylindazone (R (+) -IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R (+) -Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) [1][2][3].
CAS Number
54197-31-8
Product Name Alternative
R (+) -IAA-94
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/r-plus-methylindazone.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)COC1=CC2=C(C([C@@](C)(C3CCCC3)C2)=O)C(Cl)=C1Cl
Molecular Formula
C17H18Cl2O4
Molecular Weight
357.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90 (6) :779-98.|[2]Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244 (4911) :1469-72.|[3]Xiaoqin Fan, et al. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int J Oncol. 2015 Oct;47 (4) :1485-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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