Products for Research Use Only
RegisterLogin

(Rac) -Modipafant

CAT: 0804-HY-108908-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-108908-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(Rac) -Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac) -Modipafant prevents dengue infection[1][2][3].
CAS Number
122956-68-7
Product Name Alternative
UK-74505
UNSPSC
12352005
Target
Dengue Virus; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rac-modipafant.html
Purity
98.15
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=C(N3C(C)=NC4=C3C=CN=C4)C=C2)NC(C)=C(C(NC5=NC=CC=C5)=O)C1C6=CC=CC=C6Cl)OCC
Molecular Formula
C34H29ClN6O3
Molecular Weight
605.09
References & Citations
[1]O'Connor BJ, et al. Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. Am J Respir Crit Care Med. 1994;150 (1) :35-40.|[2]Alabaster VA, et al. UK-74,505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo. Agents Actions Suppl. 1991;34:221-227.|[3]Parry MJ, Alabaster VA, et al. Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity. J Lipid Mediat Cell Signal. 1994;10 (3) :251-268.|[4]Guerrero AT, et al. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia [published correction appears in Naunyn Schmiedebergs Arch Pharmacol. 2013 Apr;386 (4) :351. Zaperlon, Ana C [corrected to Zarpelon, Ana C]]. Naunyn Schmiedebergs Arch Pharmacol. 2013;386 (1) :51-59.|[5]Souza DG, et al. Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection. Proc Natl Acad Sci U S A. 2009;106 (33) :14138-14143.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Related Products

CatalogName
HY-108908AModipafant
HY-145817-01(Rac) -lunresertib
HY-135653A-01(Rac) -EC5026
HY-103519-01Rac-BHFF
HY-116463D-01(Rac) -E1R
HY-141495-01(Rac) -Razpipadon
HY-116830A(Rac) -BRD0705
HY-160187A-01(Rac) -AAA
HY-13642A-01(Rac) -RG108
HY-W475120(Rac) -Dihydrocarveol

Alternative Products

CatalogName
sc-505389Rac-Modipafant
T28081-01(Rac) -Modipafant
MBS5777778(Rac)-Modipafant
sc-487936Rac-Modipafant-d4
MBS5783012Modipafant
AR-E10828-01Rac-Etrasimod (rac-APD334)
A11136-10(Rac) -PF-4136309 ((Rac) -INCB8761) 10mg
A11136-5(Rac) -PF-4136309 ((Rac) -INCB8761) 5mg
AR-E10084-01Rac-Adrenaline-d3 (rac-Epinephrine-d3)
AR-E10089-01Rac-Epinephrine-d6 (rac-Adrenaline-d6)

Popular Products