Imperatoxin A

Imperatoxin A Catalog number: MDP0714 CAS Number: N/A Sequence: Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg (Reported disulfide bonds between Cys3-Cys17, Cys10-Cys21, and Cys16-Cys32) Amount: 100 ug Molecular Weight: 3758.4 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: Gurrola GB, Capes EM, Zamudio FZ, Possani LD, Valdivia HH. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors Pharmaceuticals (Basel). 2010 Apr 1;3(4):1093-1107. 2: Simeoni I, Rossi D, Zhu X, García J, Valdivia HH, Sorrentino V. Imperatoxin A (IpTx(a)) from Pandinus imperator stimulates [(3)H]ryanodine binding to RyR3 channels FEBS Lett. 2001 Nov 9;508(1):5-10. 3: Zamudio FZ, Gurrola GB, Arévalo C, Sreekumar R, Walker JW, Valdivia HH, Possani LD. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors FEBS Lett. 1997 Apr 1;405(3):385-9. 4: Dulhunty AF, Curtis SM, Watson S, Cengia L, Casarotto MG. Multiple actions of imperatoxin A on ryanodine receptors: interactions with the II-III loop "A" fragment J Biol Chem. 2004 Mar 19;279(12):11853-62. 5: Gurrola GB, Arévalo C, Sreekumar R, Lokuta AJ, Walker JW, Valdivia HH. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor J Biol Chem. 1999 Mar 19;274(12):7879-86. 6: Samsó M, Trujillo R, Gurrola GB, Valdivia HH, Wagenknecht T. Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor J Cell Biol. 1999 Jul 26;146(2):493-9. 7: Shtifman A, Ward CW, Wang J, Valdivia HH, Schneider MF. Effects of imperatoxin A on local sarcoplasmic reticulum Ca(2+) release in frog skeletal muscle Biophys J. 2000 Aug;79(2):814-27. 8: Nabhani T, Zhu X, Simeoni I, Sorrentino V, Valdivia HH, García J. Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3 Biophys J. 2002 Mar;82(3):1319-28. 9: Lee CW, Lee EH, Takeuchi K, Takahashi H, Shimada I, Sato K, Shin SY, Kim DH, Kim JI. Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A Biochem J. 2004 Jan 15;377(Pt 2):385-94. 10: Tripathy A, Resch W, Xu L, Valdivia HH, Meissner G. Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle J Gen Physiol. 1998 May;111(5):679-90.
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Catalog Number: MDP0714 (100 ug)

0.15

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