(R)-Equol

(R)-Equol

• CAS Number: 221054-79-1
• UNSPSC Description: (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/_R_-Equol.html
• Purity: 98.93
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming)
• Smiles: OC1=CC=C2C[C@H](C3=CC=C(O)C=C3)COC2=C1
• Molecular Weight: 242.274
• References & Citations: [1]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9.|[2]Magee PJ, et al. Daidzein, R-(+)equol and S-(-)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2. Eur J Nutr. 2014 Feb;53(1):345-50.|[3]Brown NM, et al. The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer. Carcinogenesis. 2010 May;31(5):886-93.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported