(R)-MPH-220

(R)-MPH-220

• UNSPSC Description: (R)-MPH-220 is the R isomer of MPH-220 (HY-148516). MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].
• Target Antigen: Myosin
• Type: Reference compound
• Related Pathways: Cytoskeleton
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/r-mph-220.html
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming)
• Smiles: O[C@]12C(N(C3=CC=C(N4CCOCC4)C=C3)CC2)=NC5=C(C=C(S5)C)C1=O
• Molecular Weight: 383.46
• References & Citations: [1]Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183(2):335-346.e13.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported