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Amoxapine (Standard)

CAT: 0804-HY-B0991R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0991R-01Size:10 mg
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Description
Amoxapine (Standard) is the analytical standard of Amoxapine. This product is intended for research and analytical applications. Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death[1][2][3].
CAS Number
14028-44-5
Product Name Alternative
CL-67772 (Standard)
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Bacterial; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Autophagy; Others
Field of Research
Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/amoxapine-standard.html
Purity
99.97
Smiles
ClC1=CC=C(OC2=CC=CC=C2N=C3N4CCNCC4)C3=C1
Molecular Formula
C17H16ClN3O
Molecular Weight
313.78
Precautions
H302
References & Citations
[1]Wang J, et al. FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy. Microbiol Spectr. 2022 Oct 26;10 (5) :e0250922.|[2]Delgado C, et al. Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria. Br J Pharmacol. 1986 Feb;87 (2) :317-25.|[3]Maudhuit C, et al. Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33 (8) :1017-25.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

Chemical Information

Amoxapine

Amoxapine can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number14028-44-5
PubChem CID2170
IUPAC Name8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
Molecular FormulaC17H16ClN3O
Molecular Weight313.8
XLogP2.6
Topological Polar Surface Area36.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count22
Formal Charge0
Complexity424
SMILES
C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
InChI
InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChIKey
QWGDMFLQWFTERH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amoxapine
CAS: 14028-44-5
CID: 2170
Formula: C17H16ClN3O
MW: 313.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight313.8
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass313.0981898
Monoisotopic Mass313.0981898
Topological Polar Surface Area36.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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