Amoxapine

• UNSPSC Description:

  Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death[1][2][3].

• Target Antigen:

  Autophagy; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Autophagy

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Amoxapine.html

• Purity:

  99.93

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC=C(OC2=CC=CC=C2N=C3N4CCNCC4)C3=C1

• Molecular Weight:

  313.788

• References & Citations:

  [1]Wang J, et al. FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy. Microbiol Spectr. 2022 Oct 26;10(5):e0250922.|[2]Delgado C, Manzanares J, Tamargo J, Valenzuela C. Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria. Br J Pharmacol. 1986 Feb;87(2):317-25.|[3]Maudhuit C, et al. Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33(8):1017-25.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  14028-44-5