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TLQP-21

CAT: 0804-HY-P1345Size: 1 EachDry Ice: NoHazardous: No
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Description
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM) . TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2].
CAS Number
869988-94-3
UNSPSC
12352209
Target
Complement System
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tlqp-21.html
Solubility
H2O
Smiles
C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@H](CC3=CN=CN3)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]6N(C(=O)[C@H]7N(C([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CC(C)C)=O)CCC(N)=O)=O)CCC7)CCC6)C)=O)CO)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)=O)=O)=O)C)=O)CC(C)C)=O)CCC1)N8[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C)=O)CCC8
Molecular Formula
C107H170N40O26
Molecular Weight
2432.75
References & Citations
[1]Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21 (1) :130.|[2]Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22 (12) :1744-1753.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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