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Pyridoclax

CAT: 0804-HY-12527-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12527-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyridoclax is a potential Mcl-1 inhibitor.
CAS Number
1651890-44-6
Product Name Alternative
MR-29072
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pyridoclax.html
Purity
99.95
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CC1=CC(C2=NC=C(C3=CC=CN=C3)C=C2/C=C/C4=CC=CC=C4)=CN=C1C5=CC=CN=C5
Molecular Formula
C29H22N4
Molecular Weight
426.51
References & Citations
[1]Gloaguen C, et al. First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58 (4) :1644-68.|[2]Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1

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