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Buntanetap

CAT: 0804-HY-16009-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16009-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Buntanetap ((+) -Phenserine) is a selective acetylcholinesterase inhibitor. Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT) . Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease[1][2][3].
CAS Number
116839-68-0
Product Name Alternative
(+) -Phenserine; ANVS401
UNSPSC
12352005
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/__addition__-PHENSERINE.html
Purity
99.71
Solubility
DMSO : 230 mg/mL (ultrasonic)
Smiles
CN1[C@@](N(C)CC2)([H])[C@@]2(C)C3=C1C=CC(OC(NC4=CC=CC=C4)=O)=C3
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
References & Citations
[1]Fang C, et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. J Prev Alzheimers Dis. 2023;10 (1) :25-33.|[2]Chen XQ, et al. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 7;13 (12) :2109. |[3]Brossi A , Pei XF Greig NH (1996) Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties. Australian Journal of Chemistry 49, 171-181.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein

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