Buntanetap

• Description :

  Buntanetap ((+) -Phenserine) is a selective acetylcholinesterase inhibitor. Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT) . Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease[1][2][3].

• Product Name Alternative :

  (+) -Phenserine; ANVS401

• UNSPSC :

  12352005

• Target :

  α-synuclein

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/__addition__-PHENSERINE.html

• Purity :

  99.71

• Solubility :

  DMSO : 230 mg/mL (ultrasonic)

• Smiles :

  CN1[C@@](N(C)CC2)([H])[C@@]2(C)C3=C1C=CC(OC(NC4=CC=CC=C4)=O)=C3

• Molecular Formula :

  C20H23N3O2

• Molecular Weight :

  337.42

• References & Citations :

  [1]Fang C, et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. J Prev Alzheimers Dis. 2023;10 (1) :25-33.|[2]Chen XQ, et al. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 7;13 (12) :2109. |[3]Brossi A , Pei XF Greig NH (1996) Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties. Australian Journal of Chemistry 49, 171-181.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  α-synuclein

• CAS Number :

  [116839-68-0]