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Buntanetap

CAT: 0013-GTR19202882-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19202882-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Buntanetap ((+) -Phenserine) is an orally bioavailable small molecule inhibitor targeting toxic proteins implicated in neurodegeneration. It is utilized in preclinical research for Alzheimer's and Parkinson's disease, with studies demonstrating its effects in reducing amyloid-β and tau pathology in both cellular and animal models.
CAS Number
116839-68-0
Product Name Alternative
BetaAmyloid, Beta Amyloid, cholinesterase, ANV S401, ANVS401, Amyloid-β, b Amyloid, bAmyloid, AChE., AChE, (+) Phenserine, (+) Phenserine, (+) -Phenserine, Huntingtin, Phenserine, β Amyloid, α-synuclein, βAmyloid
Field of Research
Neuroscience
Purity
98.20% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.82 mM) ; DMSO:200 mg/mL (592.73 mM)
Smiles
C[C@@]12C=3C (N (C) [C@@]1 (N (C) CC2) [H]) =CC=C (OC (NC4=CC=CC=C4) =O) C3
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Buntanetap

Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).

CAS Number116839-68-0
PubChem CID11249342
IUPAC Name[(3aS,8bR)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamate
Molecular FormulaC20H23N3O2
Molecular Weight337.4
XLogP2.3
Topological Polar Surface Area44.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity507
SMILES
C[C@]12CCN([C@H]1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C
InChI
InChI=1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m0/s1
InChIKey
PBHFNBQPZCRWQP-AZUAARDMSA-N
Chemical Structure
2D Structure
2D structure of Buntanetap
CAS: 116839-68-0
CID: 11249342
Formula: C20H23N3O2
MW: 337.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.4
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass337.17902698
Monoisotopic Mass337.17902698
Topological Polar Surface Area44.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-16009-01Buntanetap
HY-16009B-01Buntanetap (L-Tartrate)
T85929-01Buntanetap L-Tartrate

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