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Diminazene (aceturate)

CAT: 0804-HY-12404-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12404-01Size:100 mg
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Description
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].
CAS Number
908-54-3
Product Name Alternative
Diminazene (diaceturate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin-converting Enzyme (ACE) ; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diminazene-aceturate.html
Purity
99.31
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CNC(C)=O.N=C(C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(O)CNC(C)=O
Molecular Formula
C22H29N9O6
Molecular Weight
515.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Kuriakose S, et al. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS One. 2012;7 (11) :e48696.|[2]Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21 (2) :342-5.|[3]Castardeli C, et al. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Trypanosoma
Citation 01
Cell Metab. 2022 Mar 1;34 (3) :424-440.e7.|Drug Deliv Transl Res. 2025 Oct 29.|Endocrine. 2021 May;72 (2) :340-348.|Int Immunopharmacol. 2025 Aug 11:164:115325.|Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016 (25) 06272-8.|J Inflamm Res. 2023 Apr 17:16:1639-1652.|Radiat Res. 2022 Oct 1;198 (4) :325-335.|Research Square Preprint. 2021 Mar.|J Inflamm Res. 2023 Apr 17:16:1639-1652.

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