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Diminazene

CAT: 0804-HY-W342283-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W342283-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diminazene is an aromatic diamidine compound primarily utilized for the control of trypanosomiasis, a disease caused by trypanosome parasites. Diminazene primarily binds to the kinetoplast DNA (kDNA) of the trypanosomes, interfering with their replication process. Diminazene also presents avenues for novel pharmacological applications, such as acting as an activator of angiotensin-converting enzyme 2 (ACE2), and showing potential in the treatment of hypertension, rheumatoid arthritis, and as an immunomodulator[1].
CAS Number
536-71-0
UNSPSC
12352005
Hazard Statement
H302
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/diminazene.html
Smiles
N=C(C1=CC=C(C=C1)/N=N/NC2=CC=C(C(N)=N)C=C2)N
Molecular Formula
C14H15N7
Molecular Weight
281.32
Precautions
P264-P270-P330-P501
References & Citations
[1]da Silva Oliveira G L, et al. Diminazene aceturate—an antiparasitic drug of antiquity: advances in pharmacology & therapeutics[J]. Pharmacological research, 2015, 102: 138-157.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Inflamm Res. 2023 Apr 17:16:1639-1652.|Cell Metab. 2022 Mar 1;34 (3) :424-440.e7.|Drug Deliv Transl Res. 2025 Oct 29.|Endocrine. 2021 May;72 (2) :340-348.|Int Immunopharmacol. 2025 Aug 11:164:115325.|Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016 (25) 06272-8.|J Inflamm Res. 2023 Apr 17:16:1639-1652.|Radiat Res. 2022 Oct 1;198 (4) :325-335.|Research Square Preprint. 2021 Mar.

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