Dicloxacillin-13C4

Dicloxacillin-13C4

• UNSPSC Description: Dicloxacillin-13C4 is the 13C labeled Dicloxacillin[1]. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[2].
• Target Antigen: Antibiotic; Bacterial
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/dicloxacillin-13c4.html
• Solubility: 10 mM in DMSO
• Smiles: OC([C@@H]1N2[C@@](SC1(C)C)([H])[C@@H](C2=O)N[13C]([13C]3=[13C]([13CH3])ON=C3C4=C(C=CC=C4Cl)Cl)=O)=O
• Molecular Weight: 474.30
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25.|[3]Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun54(6):2391-400.|[4]John Chu, et al. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol. 2016 Dec12(12):1004-1006.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported