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α-NETA

CAT: 0804-HY-138097-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138097-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM) . α-NETA has anti-cancer activity[1][2].
CAS Number
115066-04-1
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Chemerin Receptor; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α-neta.html
Purity
98.0
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(CC[N+](C)(C)C)C1=CC=CC2=C1C=CC=C2.[I-]
Molecular Formula
C16H20INO
Molecular Weight
369.24
References & Citations
[1]Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2- (alpha-naphthoyl) ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20 (9) :751-71.|[2]Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9 (12) :e112925.|[3]Qiao L, et al. α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway. FASEB J. 2019 Nov;33 (11) :12760-12767.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; ALDH1

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