α-NETA

α-NETA

• CAS Number: 115066-04-1
• UNSPSC Description: α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity[1][2].
• Target Antigen: Aldehyde Dehydrogenase (ALDH); Apoptosis; Chemerin Receptor; Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/α-neta.html
• Smiles: O=C(CC[N+](C)(C)C)C1=CC=CC2=C1C=CC=C2.[I-]
• Molecular Weight: 369.24
• References & Citations: [1]Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20(9):751-71.|[2]Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9(12):e112925.|[3]Qiao L, et al. α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway. FASEB J. 2019 Nov;33(11):12760-12767.
• Shipping Conditions: Room Temperature