α-NETA

• Description:

  α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM) . α-NETA has anti-cancer activity[1][2].

• UNSPSC:

  12352005

• Target:

  Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Chemerin Receptor; Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/α-neta.html

• Purity:

  98.0

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  O=C(CC[N+](C)(C)C)C1=CC=CC2=C1C=CC=C2.[I-]

• Molecular Formula:

  C16H20INO

• Molecular Weight:

  369.24

• References & Citations:

  [1]Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2- (alpha-naphthoyl) ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20 (9) :751-71.|[2]Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9 (12) :e112925.|[3]Qiao L, et al. α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway. FASEB J. 2019 Nov;33 (11) :12760-12767.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; ALDH1

• CAS Number:

  [115066-04-1]