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XSJ-10

CAT: 0804-HY-157740-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157740-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XSJ-10 is a HDAC inhibitor containing a RAS/RAF protein interfering unit, with IC50s of 0.05 and 0.04 μM in PANC-1 cells and HT-29 cells. XSJ-10 can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xsj-10.html
Purity
95.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC(OC)=C(C(OC)=C1)/C=C/S(CC2=CC=C(C(NCC(NO)=O)=C2)OC)(=O)=O
Molecular Formula
C21H26N2O8S
Molecular Weight
466.50
References & Citations
[1]Wang Y, et al. Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit. J Med Chem. 2024 Feb 8;67 (3) :2066-2082.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9

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