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AN5777

CAT: 0804-HY-161696-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161696-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity [1].
CAS Number
491586-42-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/an5777.html
Purity
98.37
Solubility
10 mM in DMSO
Smiles
CC1=C(N=C(C)C(C(N/N=C/C2=CC=CC=C2O)=O)=C3)C3=CC=C1
Molecular Formula
C19H17N3O2
Molecular Weight
319.36
References & Citations
[1]Zhang S, et al. Identification of novel GSPT1 degraders by virtual screening and bioassay. Eur J Med Chem. 2024 Jul 5;273:116524.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N'-(2-hydroxybenzylidene)-2,8-dimethyl-3-quinolinecarbohydrazide
CAS Number491586-42-6
PubChem CID135435757
IUPAC NameN-[(E)-(2-hydroxyphenyl)methylideneamino]-2,8-dimethylquinoline-3-carboxamide
Molecular FormulaC19H17N3O2
Molecular Weight319.4
XLogP3.5
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity468
SMILES
CC1=C2C(=CC=C1)C=C(C(=N2)C)C(=O)N/N=C/C3=CC=CC=C3O
InChI
InChI=1S/C19H17N3O2/c1-12-6-5-8-14-10-16(13(2)21-18(12)14)19(24)22-20-11-15-7-3-4-9-17(15)23/h3-11,23H,1-2H3,(H,22,24)/b20-11+
InChIKey
ARBAVLNDKREMOX-RGVLZGJSSA-N
Chemical Structure
2D Structure
2D structure of N'-(2-hydroxybenzylidene)-2,8-dimethyl-3-quinolinecarbohydrazide
CAS: 491586-42-6
CID: 135435757
Formula: C19H17N3O2
MW: 319.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight319.4
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass319.132076794
Monoisotopic Mass319.132076794
Topological Polar Surface Area74.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity468
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T88210-01AN5777

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