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Ganodermanontriol

CAT: 0804-HY-N1506-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1506-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP) -damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity[1][2].
CAS Number
106518-63-2
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Epigenetic Reader Domain; p38 MAPK
Type
Natural Products
Related Pathways
Epigenetics; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ganodermanontriol.html
Purity
97.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(C)C(CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC[C@H](O)[C@](C)(O)CO)CC[C@](C)4C3=CC[C@@]12[H])=O
Molecular Formula
C30H48O4
Molecular Weight
472.70
Precautions
H315, H319, H335
References & Citations
[1]Kennedy EM, et al. Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. J Nat Prod. 2011 Nov 28;74 (11) :2332-7.|[2]Ha do T, et al. In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. Ethnopharmacol. 2013 Dec 12;150 (3) :875-85.|[3]Jedinak A, Thyagarajan-Sahu A, Jiang J, Sliva D. Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. Int J Oncol. 2011;38 (3) :761-767. |[4]Park CH, et al. The Anti-Melanogenic Effects of Ganodermanontriol from the Medicinal Mushroom Ganoderma lucidum through the Regulation of the CREB and MAPK Signaling Pathways in B16F10 Cells. Molecules. 2024 Aug 22;29 (16) :3976.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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