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Ermanin

CAT: 0804-HY-N3848-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3848-03Size:25 mg
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Description
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties[1][2].
CAS Number
20869-95-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; COX; Influenza Virus; NO Synthase
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ermanin.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(OC)=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13
Molecular Formula
C17H14O6
Molecular Weight
314.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Sandeep Appunni, et al. Targeting PknB, an Eukaryotic-Like serine/threonine Protein Kinase of Mycobacterium Tuberculosis With Phytomolecules. Comput Biol Chem. 2017 Apr;67:200-204.|[2]Jih-Jung Chen, et al. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents From the Rhizomes of Curcuma Zedoaria. Molecules. 2016 Oct 17;21 (10) :1385.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; iNOS

Chemical Information

Ermanin

3,4'-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. It has a role as an antineoplastic agent, an antimycobacterial drug, an anti-inflammatory agent, an apoptosis inducer and a plant metabolite. It is a dimethoxyflavone and a dihydroxyflavone. It is functionally related to a kaempferol.

CAS Number20869-95-8
PubChem CID5352001
IUPAC Name5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)chromen-4-one
Molecular FormulaC17H14O6
Molecular Weight314.29
XLogP2.5
Topological Polar Surface Area85.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity479
SMILES
COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC
InChI
InChI=1S/C17H14O6/c1-21-11-5-3-9(4-6-11)16-17(22-2)15(20)14-12(19)7-10(18)8-13(14)23-16/h3-8,18-19H,1-2H3
InChIKey
RJCJVIFSIXKSAH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ermanin
CAS: 20869-95-8
CID: 5352001
Formula: C17H14O6
MW: 314.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight314.29
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass314.07903816
Monoisotopic Mass314.07903816
Topological Polar Surface Area85.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TBW00458Ermanin
TRC-E658516-75MGErmanin-D3

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