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Tinostamustine (hydrochloride)

CAT: 0804-HY-101780ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101780ASize:1 Each
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Description
Tinostamustine hydrochloride (EDO-S101 hydrochloride) is a compound with anti-multiple myeloma activity and the ability to promote CD38 expression. Tinostamustine hydrochloride enhances the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab by increasing the acetylation level of histone H3. Tinostamustine hydrochloride can increase the expression of MICA and MICB, thereby activating NK cells. Tinostamustine hydrochloride can significantly delay tumor growth and improve the survival rate of mice[1].
CAS Number
1793059-58-1
Product Name Alternative
EDO-S101 (hydrochloride) ; NL-101 (hydrochloride)
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tinostamustine-hydrochloride.html
Smiles
O=C(NO)CCCCCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C.Cl
Molecular Formula
C19H29Cl3N4O2
Molecular Weight
451.82
References & Citations
[1]Mehrling T, et al. The Alkylating-HDAC Inhibition Fusion Principle: Taking Chemotherapy to the Next Level with the First in Class Molecule EDO-S101. Anticancer Agents Med Chem. 2016;16 (1) :20-8.|[2]Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
MBS132798Tinostamustine
MBS5812732Tinostamustine HCl
S8769-1gTinostamustine (EDO-S101)
407990Tinostamustine free base
A18342-100Tinostamustine (EDO-S101) 100mg
A18342-50Tinostamustine (EDO-S101) 50mg
A18342-25Tinostamustine (EDO-S101) 25mg
A18342-10Tinostamustine (EDO-S101) 10mg
A18342-1Tinostamustine (EDO-S101) 1mg
A18342-5Tinostamustine (EDO-S101) 5mg

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