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Dansylcadaverine

CAT: 0804-HY-D1027-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1027-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2].
CAS Number
10121-91-2
Product Name Alternative
Monodansyl cadaverine
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Autophagy
Type
Dye Reagents
Related Pathways
Autophagy
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Dansylcadaverine.html
Purity
98.80
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
NCCCCCNS(=O)(C1=CC=CC2=C1C=CC=C2N(C)C)=O
Molecular Formula
C17H25N3O2S
Molecular Weight
335.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Huff T, et al. Thymosin beta (4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescentdansylcadaverine does not abolish interaction with G-actin. FEBS Lett. 1999 Dec 24;464 (1-2) :14-20.|[2]Laha D, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014 Jan;1840 (1) :1-9.|[3]Gao L, et al. Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis. J Mol Med (Berl) . 2018;96 (9) :929-938.|[4]Cornwell MM, et al. Inhibition of the adhesion of Chinese hamster ovary cells by the naphthylsulfonamides dansylcadaverine and N- (6-aminohexyl) -5-chloro-1-naphthylenesulfonamide (W7) . Biochim Biophys Acta. 1983;762 (3) :414-419.|[5]David SA, et al. Analysis of the binding of polymyxin B to endotoxic lipid A and core glycolipid using a fluorescent displacement probe. Biochim Biophys Acta. 1992;1165 (2) :147-152.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Alternative Products

CatalogName
sc-214851BDansylcadaverine
C01249-25mgDansylcadaverine (Monodansyl cadaverine)
TBI2847-100MGDansylcadaverine, Autophagic vacuole dye

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