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Terminolic acid

CAT: 0804-HY-N7652-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7652-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research[1][2][3].
CAS Number
564-13-6
UNSPSC
12352211
Target
Bacterial; Interleukin Related
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/terminolic-acid.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]1(C[C@H]2O)[C@@](CC=C([C@]3([H])CC4(C)C)[C@]1(CC[C@]3(CC4)C(O)=O)C)([H])[C@]([C@]2([H])[C@@](C)([C@H]5O)CO)(C[C@H]5O)C
Molecular Formula
C30H48O6
Molecular Weight
504.70
References & Citations
[1]Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95.|[2]Legiawati L, et, al. In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing Il-1 and Il-6 activity, promoting Il-4 activity. /J. Pharm. Sci. & Res. Vol. 10 (9), 2018, 2142-2147.|[3]Yang GX, et al. Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells. Nat Prod Res. 2014;28 (17) :1383-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; IL-8

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