Diethyl succinate (Standard)

Diethyl succinate (Standard)

• CAS Number: 123-25-1
• UNSPSC Description: Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings[1][2].
• Target Antigen: Biochemical Assay Reagents; Reactive Oxygen Species
• Type: Reference Standards
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Others
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/diethyl-succinate-standard.html
• Smiles: O=C(OCC)CCC(OCC)=O
• Molecular Weight: 174.19
• References & Citations: [1]Zacharias NM, et al. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate. J Am Chem Soc. 2012 Jan 18;134(2):934-43.|[2]Lixiang Wang, et al. "Diethyl succinate modulates microglial polarization and activation by reducing mitochondrial fission and cellular ROS." Metabolites 11.12 (2021): 854.
• Shipping Conditions: Room temperature