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Estradiol 17- (β-D-Glucuronide)

CAT: 0804-HY-W353102Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W353102Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estradiol 17- (β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17- (β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter[1].
CAS Number
1806-98-0
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/estradiol-17-β-d-glucuronide.html
Purity
99.0
Solubility
DMSO : 4.5 mg/mL (ultrasonic; warming)
Smiles
C[C@@]12[C@](CC[C@@H]2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)([H])[C@@]4([H])[C@@](CC1)([H])C5=CC=C(O)C=C5CC4
Molecular Formula
C24H32O8
Molecular Weight
448.51
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32 (9) :947-952.|[2]Kanai N, et al. Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270 (2 Pt 2) :F326-31.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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