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L-749329

CAT: 0804-HY-117644Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117644Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-749329 ((Rac) -L-754142) is an ETA and ETB receptor antagonist, with Kis of 0.062 nM and 2.25 nM for ETA and ETB respectively. L-749329 inhibits ET-1-stimulated signaling[1].
CAS Number
159590-37-1
Product Name Alternative
(Rac) -L-754142
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/l-749329.html
Smiles
O=C(C1=CC=C(C(CCC)=C1)OC(C2=CC=C3OCOC3=C2)C(NS(=O)(C4=CC=C(C(C)C)C=C4)=O)=O)O
Molecular Formula
C28H29NO8S
Molecular Weight
539.60
References & Citations
[1]Huckle WR, et al. Effects of L-749,329, an ET (A) /ET (B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation. 2001 Apr 10;103 (14) :1899-905.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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