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GNE0877

CAT: 0804-HY-15796-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15796-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience[1].
CAS Number
1374828-69-9
UNSPSC
12352005
Hazard Statement
H317, H319
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GNE0877.html
Purity
99.81
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC1=NN(C(C)(C)C#N)C=C1NC2=NC=C(C(F)(F)F)C(NC)=N2
Molecular Formula
C14H16F3N7
Molecular Weight
339.32
Precautions
H317, H319
References & Citations
[1]Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57 (3) :921-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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