Acetohydroxamic acid

• Description:

  Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV[1][2][3].

• Product Name Alternative:

  N-Hydroxyacetamide

• UNSPSC:

  12352211

• Hazard Statement:

  H360

• Target:

  Bacterial; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Acetohydroxamic-acid.html

• Concentration:

  10mM

• Purity:

  98.66

• Solubility:

  DMSO : 233.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  CC (NO) =O

• Molecular Formula:

  C2H5NO2

• Molecular Weight:

  75.07

• Precautions:

  H360

• References & Citations:

  [1]Sharma M, et al. Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225. Indian J Microbiol. 2012 Mar;52 (1) :76-82.|[2]Umamaheshwari RB, et al., Receptor-mediated targeting of lipobeads bearing acetohydroxamic acid for eradication of Helicobacter pylori. J Control Release. 2004 Sep 14;99 (1) :27-40.|[3]Liu YH, et al., Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro. Drug Des Devel Ther. 2017 Jul 13;11:2139-2147.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  546-88-3