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Cefetamet (sodium)

CAT: 0804-HY-A0111ASize: 1 EachDry Ice: NoHazardous: No
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Description
Cefetamet (Ro 15-8074) sodium is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil. Cefetamet sodium binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet sodium has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet sodium kills and lyses Treponema pallidum. Cefetamet sodium can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis[1][2][3][4][5].
CAS Number
65243-25-6
Product Name Alternative
Ro15-8074/001; Deacetoxycefotaxime (sodium)
UNSPSC
12352005
Target
Antibiotic; Bacterial; Drug Metabolite; Penicillin-binding protein (PBP)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cefetamet-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(O[Na])C(N1[C@@]([H])([C@@H](C1=O)NC(/C(C2=CSC(N)=N2)=N\OC)=O)SC3)=C3C
Molecular Formula
C14H14N5NaO5S2
Molecular Weight
419.41
References & Citations
[1]Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993;45 (4) :589-621.|[2]Wang W, et al. Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog. Eur J Drug Metab Pharmacokinet. 2015 Dec;40 (4) :401-7.|[3]Wise R, et al. In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Antimicrob Agents Chemother. 1986 Jun;29 (6) :1067-72. |[4]Angehrn P, et al. In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil. Eur J Clin Microbiol Infect Dis. 1989 Jun;8 (6) :536-43. |[5]Fitzgerald TJ. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis. Antimicrob Agents Chemother. 1992 Mar;36 (3) :598-602.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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