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Cefetamet

CAT: 0804-HY-A0111-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0111-01Size:5 mg
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Description
Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil. Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis[1][2][3][4][5].
CAS Number
65052-63-3
Product Name Alternative
Ro 15-8074; Deacetoxycefotaxime
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Antibiotic; Bacterial; Drug Metabolite; Penicillin-binding protein (PBP)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cefetamet.html
Purity
99.42
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O
Molecular Formula
C14H15N5O5S2
Molecular Weight
397.43
Precautions
H302, H315, H320, H335
References & Citations
[1]Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993;45 (4) :589-621.|[2]Wang W, et al. Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog. Eur J Drug Metab Pharmacokinet. 2015 Dec;40 (4) :401-7. |[3]Wise R, et al. In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Antimicrob Agents Chemother. 1986 Jun;29 (6) :1067-72. |[4]Angehrn P, et al. In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil. Eur J Clin Microbiol Infect Dis. 1989 Jun;8 (6) :536-43. |[5]Fitzgerald TJ. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis. Antimicrob Agents Chemother. 1992 Mar;36 (3) :598-602.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β-lactam

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BA1100-25Cefetamet
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MBS5776697Cefetamet Hydrochloride
TRC-C242772-1MGCefetamet-d3
sc-268676ACefetamet acid
FC44060-01Cefetamet pivoxyl

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