SPEN-IN-1

CAT: 0804-HY-152038-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-152038-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing[1].

CAS Number

2863686-82-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/spen-in-1.html

Purity

97.09

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

C1(C2=NC3=CC=CC=C3N2)=NNC4=C1C=C(C5=CC=CC(OCC6=CC=CC=C6)=C5)C=C4

Molecular Formula

C27H20N4O

Molecular Weight

416.47

Precautions

H302, H315, H319

References & Citations

[1]Aguilar R, et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature. 2022 Apr;604 (7904) :160-166.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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