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LXQ46

CAT: 0804-HY-160514-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160514-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LXQ46 is an orally active inhibitor for protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 0.190 μM. LXQ46 enhances insulin and leptin signaling pathways in insulin-resistant C2C12. LXQ46 ameliorates type 2 diabetes and increases insulin tolerance in mouse models[1].
CAS Number
2097148-94-0
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lxq46.html
Purity
99.14
Smiles
BrC1=C(O)C(O)=CC(C2=NC=C(C3=CC=C(OC4=CC=C(C=C4)OCC)C=C3)O2)=C1Br
Molecular Formula
C23H17Br2NO5
Molecular Weight
547.19
References & Citations
[1]Li X, et al., Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors. Eur J Med Chem. 2019 Mar 15;166:178-185.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T88568-01LXQ46

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