Products for Research Use Only
RegisterLogin

S-777469

CAT: 0804-HY-145153-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-145153-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism[1][2].
CAS Number
885496-53-7
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-777469.html
Purity
98.19
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C)=C(CC)N(CC2=CC=C(C=C2)F)C1=O)NC3(CCCCC3)C(O)=O
Molecular Formula
C23H27FN2O4
Molecular Weight
414.47
References & Citations
[1]Odan M, et al. Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2803-6. |[2]Haruna T, et al. S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission. Pharmacology. 2015;95 (1-2) :95-103.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Related Products

CatalogName
HY-125845B(S, S, S) -AHPC
HY-120217A(S, S, S) -VH032
HY-172298(R, S, S, S) -Orlistat
HY-112078B(S, S, S) -AHPC-Me
HY-125845A-01(S, S, S) -AHPC (hydrochloride)
HY-123109A-01(S, S, S) -AHPC-Boc
HY-78931B-01(S, S, S, S, R) -Boc-Dap-NE
HY-130671B(S, S) -DPPG
HY-122715(S, S) -D211
HY-137428-01(S, S) -EDDS

Alternative Products

CatalogName
BA5218-10S-777469
465057-01(S, S, S, S) -Nebivolol
TRC-N381313-50MG(S,S,S,S)-Nebivolol
AR-P02421-01(S, S, S, S) -Benzylposaconazole
AR-O01425-01(S, S, S, S) -Orlistat
465056S, S, S, S, S-Trandolapril Hydrochloride
TRC-T713490-1GS,S,S,S,S-Trandolapril Hydrochloride
465061(+) - (S, S, S) -Ciramadol
465059(S, S, S) -Aprepitant
TRC-C490005-100MG(+)-(S,S,S)-Ciramadol

Popular Products