Sorbitol dehydrogenase-IN-1

Sorbitol dehydrogenase-IN-1

• CAS Number: 300551-49-9
• UNSPSC Description: Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol[1].
• Target Antigen: Aldehyde Dehydrogenase (ALDH); Others
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Others
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/sorbitol-dehydrogenase-in-1.html
• Purity: 98.70
• Solubility: DMSO : 40 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O[C@@H](C1=NC(N2[C@H](C)CN(C[C@@H]2C)C3=NC(C)=NC(C)=N3)=CC=N1)C
• Molecular Weight: 343.43
• References & Citations: [1]Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported