Sorbitol dehydrogenase-IN-1

• UNSPSC Description:

  Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol[1].

• Target Antigen:

  Aldehyde Dehydrogenase (ALDH); Others

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/sorbitol-dehydrogenase-in-1.html

• Purity:

  98.70

• Solubility:

  DMSO : 40 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O[C@@H](C1=NC(N2[C@H](C)CN(C[C@@H]2C)C3=NC(C)=NC(C)=N3)=CC=N1)C

• Molecular Weight:

  343.43

• References & Citations:

  [1]Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  300551-49-9