Carvacrol

• Description:

  Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations[1][2].

• Product Name Alternative:

  Cymophenol

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H314, H411

• Target:

  Apoptosis; Bacterial; Endogenous Metabolite; Fungal; Notch

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/carvacrol.html

• Concentration:

  10mM

• Purity:

  99.99

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC (C (C) C) =CC=C1C

• Molecular Formula:

  C10H14O

• Molecular Weight:

  150.22

• Precautions:

  H302, H314, H411

• References & Citations:

  [1]Khan F, et al. Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Anticancer Agents Med Chem. 2019 Jul 31.|[2]Suntres ZE, et al. The bioactivity and toxicological actions of carvacrol. Crit Rev Food Sci Nutr. 2015;55 (3) :304-18.|[3]Kara M, et al. Supplemental carvacrol can reduce the severity of inflammation by influencing the production of mediators of inflammation. Inflammation. 2015;38 (3) :1020-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 3

• CAS Number:

  499-75-2