Products for Research Use Only
RegisterLogin

Tiron

CAT: 0804-HY-D0261-04Size: 50 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-D0261-04Size:50 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[1][2][3].
CAS Number
149-45-1
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Apoptosis; Others
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tiron.html
Purity
99.94
Solubility
DMSO : 80 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=C(O)C(O)=CC(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+]
Molecular Formula
C6H4Na2O8S2
Molecular Weight
314.20
Precautions
H315, H319
References & Citations
[1]Krishna CM, et al. The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys. 1992 Apr;294 (1) :98-106. 2. |[2]El-Sherbeeny NA, et al. Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling. Int Immunopharmacol. 2016 Oct;39:172-180. |[3]Jiang P, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017 Jul;44 (7) :760-770. |[4]Lu J, et al. Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts. PLoS One. 2016 Aug 3;11 (8) :e0159998. |[5]Monticone M, et al. NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression. PLoS One. 2014 Feb 28;9 (2) :e90085.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Tiron

Tiron is an organic molecular entity.

CAS Number149-45-1
PubChem CID9001
IUPAC Namedisodium;4,5-dihydroxybenzene-1,3-disulfonate
Molecular FormulaC6H4Na2O8S2
Molecular Weight314.2
Topological Polar Surface Area172
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Heavy Atom Count18
Formal Charge0
Complexity413
SMILES
C1=C(C=C(C(=C1O)O)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C6H6O8S2.2Na/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;/h1-2,7-8H,(H,9,10,11)(H,12,13,14);;/q;2*+1/p-2
InChIKey
ISWQCIVKKSOKNN-UHFFFAOYSA-L
Chemical Structure
2D Structure
2D structure of Tiron
CAS: 149-45-1
CID: 9001
Formula: C6H4Na2O8S2
MW: 314.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight314.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Exact Mass313.91429799
Monoisotopic Mass313.91429799
Topological Polar Surface Area172 Ų
Heavy Atom Count18
Formal Charge0
Complexity413
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Alternative Products

CatalogName
OR1015243-01Tiron
40000088-2Tiron Monohydrate
GTR19222734-01Tiron free acid
60001-01Tiron Monohydrate extrapure, 98%
323335-01Tiron AR Metal (pH) Indicator
271100010Tiron AR Metal (PM) Indicator
58661995-25gTiron (1,2-Dihydroxybenzene-3,5-disulfonic acid disodium salt) C6H6Na2O9S2

Popular Products