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Tiron

CAT: 0804-HY-D0261-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-D0261-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[1][2][3].
CAS Number
149-45-1
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Apoptosis; Others
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tiron.html
Purity
99.94
Solubility
DMSO : 80 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=C(O)C(O)=CC(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+]
Molecular Formula
C6H4Na2O8S2
Molecular Weight
314.20
Precautions
H315, H319
References & Citations
[1]Krishna CM, et al. The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys. 1992 Apr;294 (1) :98-106. 2. |[2]El-Sherbeeny NA, et al. Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling. Int Immunopharmacol. 2016 Oct;39:172-180. |[3]Jiang P, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017 Jul;44 (7) :760-770. |[4]Lu J, et al. Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts. PLoS One. 2016 Aug 3;11 (8) :e0159998. |[5]Monticone M, et al. NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression. PLoS One. 2014 Feb 28;9 (2) :e90085.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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