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GKA50

CAT: 0804-HY-15671-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15671-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) . GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats[1][2][3][4].
CAS Number
851884-87-2
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gka50.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 46 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC=C(NC(C2=CC(O[C@@H](C)CC3=CC=CC=C3)=CC(O[C@@H](C)COC)=C2)=O)N=C1)O
Molecular Formula
C26H28N2O6
Molecular Weight
464.51
Precautions
H302, H413
References & Citations
[1]Coope GJ, et al. Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br J Pharmacol. 2006 Oct;149 (3) :328-35.|[2]McGlasson L, et al. The glucokinase activator GKA50 causes an increase in cell volume and activation of volume-regulated anion channels in rat pancreatic β-cells. Mol Cell Endocrinol. 2011 Aug 6;342 (1-2) :48-53.|[3]Johnson D, et al. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. Diabetes. 2007;56 (6) :1694-1702.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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