Products for Research Use Only
RegisterLogin

PTH (1-37) (human)

CAT: 0804-HY-P4823-01Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P4823-01Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PTH (1-37) (human) is a fragment of parathyroid hormone (PTH) . pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis[1][2][3].
CAS Number
136799-54-7
UNSPSC
12352209
Target
Thyroid Hormone Receptor
Type
Peptides
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pth-1-37-human.html
Purity
99.91
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N
Molecular Formula
C195H316N58O54S2
Molecular Weight
4401.08
References & Citations
[1]Tsai JA, et al. Parathyroid hormone-related protein (1-37) induces cAMP response in human osteoblast-like cells. Calcif Tissue Int. 1998 Mar;62 (3) :250-4.|[2]Schmitt CP, et al. Intermittent administration of parathyroid hormone (1-37) improves growth and bone mineral density in uremic rats. Kidney Int. 2000 Apr;57 (4) :1484-92.|[3]Stephan S, et al. Intermittent administration of the circulating form of human parathyroid hormone (hPTH-1-37) prevents bone loss in ovariectomized rats. Eur J Med Res. 2007 Jan 31;12 (1) :13-20.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

CID 172880656
CAS Number136799-54-7
PubChem CID172880656
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acid
Molecular FormulaC195H316N58O54S2
Molecular Weight4401
XLogP-17.2
Topological Polar Surface Area1890
Hydrogen Bond Donor Count63
Hydrogen Bond Acceptor Count65
Rotatable Bond Count155
Heavy Atom Count309
Formal Charge0
Complexity10500
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC5=CNC=N5)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N
InChI
InChI=1S/C195H316N58O54S2/c1-26-104(22)157(253-172(285)123(53-58-151(267)268)227-187(300)142(90-256)248-191(304)154(101(16)17)249-159(272)112(199)88-254)192(305)231-120(50-55-144(201)258)167(280)234-128(70-96(6)7)175(288)228-125(60-67-309-25)170(283)240-134(77-109-85-210-92-217-109)179(292)242-136(79-145(202)259)181(294)232-126(68-94(2)3)160(273)215-87-148(262)220-114(44-32-35-61-196)161(274)239-133(76-108-84-209-91-216-108)178(291)236-130(72-98(10)11)176(289)241-138(81-147(204)261)183(296)247-141(89-255)186(299)229-124(59-66-308-24)169(282)225-121(51-56-149(263)264)165(278)223-118(48-39-65-213-195(207)208)171(284)250-155(102(18)19)189(302)230-122(52-57-150(265)266)168(281)238-132(75-107-83-214-113-43-31-30-42-111(107)113)177(290)235-129(71-97(8)9)173(286)224-117(47-38-64-212-194(205)206)163(276)221-115(45-33-36-62-197)162(275)222-116(46-34-37-63-198)164(277)233-127(69-95(4)5)174(287)226-119(49-54-143(200)257)166(279)244-139(82-152(269)270)185(298)252-156(103(20)21)190(303)245-135(78-110-86-211-93-218-110)180(293)243-137(80-146(203)260)182(295)237-131(74-106-40-28-27-29-41-106)184(297)251-153(100(14)15)188(301)219-105(23)158(271)246-140(193(306)307)73-99(12)13/h27-31,40-43,83-86,91-105,112,114-142,153-157,214,254-256H,26,32-39,44-82,87-90,196-199H2,1-25H3,(H2,200,257)(H2,201,258)(H2,202,259)(H2,203,260)(H2,204,261)(H,209,216)(H,210,217)(H,211,218)(H,215,273)(H,219,301)(H,220,262)(H,221,276)(H,222,275)(H,223,278)(H,224,286)(H,225,282)(H,226,287)(H,227,300)(H,228,288)(H,229,299)(H,230,302)(H,231,305)(H,232,294)(H,233,277)(H,234,280)(H,235,290)(H,236,291)(H,237,295)(H,238,281)(H,239,274)(H,240,283)(H,241,289)(H,242,292)(H,243,293)(H,244,279)(H,245,303)(H,246,271)(H,247,296)(H,248,304)(H,249,272)(H,250,284)(H,251,297)(H,252,298)(H,253,285)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,306,307)(H4,205,206,212)(H4,207,208,213)/t104-,105-,112-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,153-,154-,155-,156-,157-/m0/s1
InChIKey
ZEKQAUSYRLLYQY-QBKSNYRVSA-N
Chemical Structure
2D Structure
2D structure of CID 172880656
CAS: 136799-54-7
CID: 172880656
Formula: C195H316N58O54S2
MW: 4401
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight4401
XLogP3-17.2
Hydrogen Bond Donor Count63
Hydrogen Bond Acceptor Count65
Rotatable Bond Count155
Exact Mass4400.3272438
Monoisotopic Mass4398.3205341
Topological Polar Surface Area1890 Ų
Heavy Atom Count309
Formal Charge0
Complexity10500
Isotope Atom Count0
Defined Atom Stereocenter Count37
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-P4849PTH-Related Protein (1-37) (human, mouse, rat)
HY-P4741LL-37 (37-1)
HY-P4825-01PTH (1-38) (human)
HY-P4817Human PTH- (1-31)
HY-P4692PTH (1-44) (human)
HY-P2283β-Amyloid (1-37) (human)
HY-P7112-01PTH, Human
HY-P4862Biotinyl-pTH (1-34) (human)
HY-P4818Human PTH- (1-31) amide
HY-P4821-01PTH (1-34) amide (human)

Alternative Products

CatalogName
4043021.05pTH (1-37) (human)
CRB1000269-01Amylin (1-37) Human
T37768β-Amyloid (1-37) (human)
MBS5818405Amylin (1-37)(human)
GTR19036056-01Amylin (1-37) (human)
MBS5818588pTH (1-37)(human)
PT-A02059-01GLP 1 Human (37 a.a.)
GTR18894304LL 37 (18-37) (human)
GTR18894303LL 37 (13-37) (human)
GTR18894502GLP-1 (1-37) (human, rat)

Popular Products