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(E) -4-Hydroxycrotonic acid

CAT: 0804-HY-100982-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100982-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E) -4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E) -4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E) -4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
CAS Number
24587-49-3
Product Name Alternative
Trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-4-hydroxycrotonic-acid.html
Purity
99.83
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/CO
Molecular Formula
C4H6O3
Molecular Weight
102.09
Precautions
H315, H319, H335
References & Citations
[1]Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. J Med Chem. 2017 Nov 9;60 (21) :9022-9039.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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