(E) -4-Hydroxycrotonic acid

• Description :

  (E) -4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E) -4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E) -4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].

• CAS Number :

  [24587-49-3]

• Product Name Alternative :

  Trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/e-4-hydroxycrotonic-acid.html

• Purity :

  99.83

• Solubility :

  DMSO : 175 mg/mL (ultrasonic)

• Smiles :

  O=C(O)/C=C/CO

• Molecular Formula :

  C4H6O3

• Molecular Weight :

  102.09

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. J Med Chem. 2017 Nov 9;60 (21) :9022-9039.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported