SQLE-IN-1

• UNSPSC Description:

  SQLE-IN-1 (compound 19) is a squalene epoxidase (SQLE) inhibitor. SQLE-IN-1 inhibits the proliferation and migration of Huh7 cells. SQLE-IN-1 inhibits the cell cholesterol generation. SQLE-IN-1 increases the expression of PTEN and inhibits PI3K and AKT[1].

• Target Antigen:

  Akt; PI3K; PTEN

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/sqle-in-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=C(F)C=C1F)(NC2=CC=C(NC3=NC(C)=NC(NC4=CC=C(C)C=C4)=C3)C=C2)=O

• Molecular Weight:

  481.52

• References & Citations:

  [1]Liu, Yayun, et al. Novel squalene epoxidase inhibitor and application thereof in preparation of anti-liver cancer drugs. China, CN116987037. 2023-11-03.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1019169-83-5