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IRF3 antibody

CAT: 0710-FNab10264Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10264Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
Interferon regulatory factor 3 (IRF-3) |IRF3
Gene ID
3661
UniProt
Q14653
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Interferon regulatory factor 3
Target
IRF3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Signal Transduction, Metabolism, Cancer, Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
24-255aa

UniProtKB · Q14653

Interferon regulatory factor 3

IRF3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14653
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IRF3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IRF-3
EC number
—
Processing
—
Secondary accessions
A8K7L2, B2RAZ3, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionImmunityInnate immunityTranscriptionTranscription regulation

Cellular component

CytoplasmMitochondrionNucleus

Disease

Disease variant

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