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Phthalide

CAT: 0804-HY-W015820-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W015820-01Size:10 g
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Description
Phthalide is a chemical scaffold. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant and blood-tumor barrier modulators[1][2][3][4].
CAS Number
87-41-2
UNSPSC
12352005
Hazard Statement
H319
Target
Bacterial; Biochemical Assay Reagents
Type
Natural Products
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/phthalide.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1OCC2=C1C=CC=C2
Molecular Formula
C8H6O2
Molecular Weight
134.13
Precautions
H319
References & Citations
[1]Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722.|[2]Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353.|[3]Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22 (12) :1176-1187.|[4]Liu X, et al. Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways. Pharmaceutical Chemistry Journal, 2024, 57 (12) : 1967-1976.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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