Phthalide

• Description :

  Phthalide is a chemical scaffold. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant and blood-tumor barrier modulators[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  Bacterial; Biochemical Assay Reagents

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/phthalide.html

• Concentration :

  10mM

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1OCC2=C1C=CC=C2

• Molecular Formula :

  C8H6O2

• Molecular Weight :

  134.13

• Precautions :

  H319

• References & Citations :

  [1]Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722.|[2]Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353.|[3]Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22 (12) :1176-1187.|[4]Liu X, et al. Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways. Pharmaceutical Chemistry Journal, 2024, 57 (12) : 1967-1976.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [87-41-2]