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10-Deacetyltaxol

CAT: 0804-HY-N1391-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1391-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].
CAS Number
78432-77-6
Product Name Alternative
10-Deacetylpaclitaxel
UNSPSC
12352005
Hazard Statement
H302
Target
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/10-deacetyltaxol.html
Purity
99.72
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(O[C@]12[C@@]([C@]3([C@@H](O)C[C@@]1([H])OC2)C)([H])[C@@H]([C@]4(C(C)(C([C@@H](O)C3=O)=C(C)[C@@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C4)C)O)OC(C7=CC=CC=C7)=O)=O
Molecular Formula
C45H49NO13
Molecular Weight
811.87
Precautions
H302
References & Citations
[1]19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44 (3) :312-9.|[2]Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A.|[3]Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2 (2) :297-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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