Gliclazide

CAT: 0804-HY-B0753-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-B0753-01Size:1 g
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Description
Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic[1].
CAS Number
[21187-98-4]
Product Name Alternative
S1702; SE1702
UNSPSC
12352005
Hazard Statement
H302
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gliclazide.html
Purity
99.58
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
O=S(C1=CC=C(C)C=C1)(NC(NN2CC3C(CCC3)C2)=O)=O
Molecular Formula
C15H21N3O3S
Molecular Weight
323.41
Precautions
H302
References & Citations
[1]Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55 (6) : p. 722-30.|[2]Lawrence, C.L., et al., Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia, 2001. 44 (8) : p. 1019-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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