Gliclazide-d4

CAT: 0931-T71981-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T71981-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1185039-30-8
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic ?-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic ?-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 ?M) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (5 and 10 ?g/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 ?g/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ) .
Smiles
N(C(NS(=O)(=O)C1=C(C(=C(C)C(=C1[2H])[2H])[2H])[2H])=O)N2CC3C(C2)CCC3
Molecular Formula
C15H17D4N3O3S
Molecular Weight
327.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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