Gliclazide-d4

• Target:

  Potassium Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic ?-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic ?-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 ?M) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (5 and 10 ?g/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 ?g/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ) .

• Smiles:

  N (C (NS (=O) (=O) C1=C (C (=C (C) C (=C1[2H]) [2H]) [2H]) [2H]) =O) N2CC3C (C2) CCC3

• Molecular Formula:

  C15H17D4N3O3S

• Molecular Weight:

  327.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1185039-30-8