Gliclazide-d4

• Target :

  Potassium Channel

• Related Pathways :

  Membrane transporter/Ion channel

• Bioactivity :

  Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic ?-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic ?-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 ?M) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (5 and 10 ?g/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 ?g/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ) .

• Smiles :

  N(C(NS(=O)(=O)C1=C(C(=C(C)C(=C1[2H])[2H])[2H])[2H])=O)N2CC3C(C2)CCC3

• Molecular Formula :

  C15H17D4N3O3S

• Molecular Weight :

  327.44

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1185039-30-8