Fenvalerate-d5

• Description :

  Fenvalerate-d5 is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Bacterial; Isotope-Labeled Compounds; Phosphatase

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease; Others

• Field of Research :

  Infection

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)C(C1=CC=C(Cl)C=C1)C(OC(C#N)C2=CC=CC(OC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])=C2)=O

• Molecular Formula :

  C25H17D5ClNO3

• Molecular Weight :

  424.93

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]E Enan, et al. Specific Inhibition of Calcineurin by Type II Synthetic Pyrethroid Insecticides. Biochem Pharmacol. 1992 Apr 15;43 (8) :1777-84.; A R Reilein, et al. Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A) . J Cell Biol. 1998 Aug 10;142 (3) :803-13.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1246815-00-8]