Fenvalerate

• Description :

  Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H319, H335, H410

• Target :

  Bacterial; Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/fenvalerate.html

• Concentration :

  10mM

• Purity :

  99.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(OC(C#N)C1=CC=CC(OC2=CC=CC=C2)=C1)C(C(C)C)C3=CC=C(Cl)C=C3

• Molecular Formula :

  C25H22ClNO3

• Molecular Weight :

  419.90

• Precautions :

  H301, H315, H319, H335, H410

• References & Citations :

  [1]E Enan, et al. Specific Inhibition of Calcineurin by Type II Synthetic Pyrethroid Insecticides. Biochem Pharmacol. 1992 Apr 15;43 (8) :1777-84.|[2]A R Reilein, et al. Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A) . J Cell Biol. 1998 Aug 10;142 (3) :803-13.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [51630-58-1]