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5MPN

CAT: 0804-HY-123981-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123981-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM) . 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines[1].
CAS Number
47208-82-2
UNSPSC
12352005
Hazard Statement
H301, H315, H318, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5mpn.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C2N=CC=C(NCCCCCO[N+]([O-])=O)C2=CC=C1
Molecular Formula
C15H19N3O4
Molecular Weight
305.33
Precautions
H301, H315, H318, H335
References & Citations
[1]Chesney J, et al. Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor. Oncotarget. 2015;6 (20) :18001-18011.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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