5MP-Propargyl

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Description

5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP) . 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation[1]. 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CAS Number

2100286-15-3

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5mp-propargyl.html

Solubility

10 mM in DMSO

Smiles

O=C(C=C1)N(CC#C)C1=C

Molecular Formula

C8H7NO

Molecular Weight

133.15

References & Citations

[1]Yingqian Zhang, et al. Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones. J Am Chem Soc. 2017 May 3;139 (17) :6146-6151.

Shipping Conditions

Room temperature

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Chemical Information

5MP-Propargyl

CAS Number	2100286-15-3
PubChem CID	90208944
IUPAC Name	5-methylidene-1-prop-2-ynylpyrrol-2-one
Molecular Formula	C8H7NO
Molecular Weight	133.15
XLogP	0.6
Topological Polar Surface Area	20.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Heavy Atom Count	10
Formal Charge	0
Complexity	254

SMILES

C=C1C=CC(=O)N1CC#C

InChI

InChI=1S/C8H7NO/c1-3-6-9-7(2)4-5-8(9)10/h1,4-5H,2,6H2

InChIKey

NRHQRYLZMFHIBT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2100286-15-3

CID: 90208944

Formula: C8H7NO

MW: 133.15

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	133.15
XLogP3	0.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	133.052763847
Monoisotopic Mass	133.052763847
Topological Polar Surface Area	20.3 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	254
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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5MP-Propargyl

Chemical Information

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